Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.
نویسندگان
چکیده
In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 99 شماره
صفحات -
تاریخ انتشار 2014